Hi Krueg, I was diagnosed with GCA and PMR in 2017. I was on 60-80mg of Pred for 8 months and then switched to Actemra. I went in the hospital once and my Rheum thought I had a relapse even thought the blood tests pointed to dehydration. I stayed on Actemra until Nov of 2021 when I was finally cleared. I have been clean since. Both meds have their pro's and con's. Pred makes you feel like Superman...until you come down. It also eats away at your bones. Actemra weakens your immune system so you become suseptible to other diseases and cancer. Coming off Pred I had pretty severe episodes of fatigue. I would just sleep most of the day. Unfortunately its one devil or the other.