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Rising PSA's after treatment - an answer

Prostate Cancer | Last Active: Jan 11 8:59am | Replies (31)

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@consultant

There's some more recent studies that show going before 0.2 has statistically better outcomes. Strangely one report cites an average SRT PSA of 0.08? Huh? Did these guys pay out of pocket or was this that low because they were doing ADT just prior? (I don't have the time right now to go over the report with a fine tooth comb I'll see if I can find the URL.)

I think it's safe to say doing SRT before 0.1 would be "aggressive" and "problematic" with the insurance company is my guess. Edit: Scratch that statement. Getting confirmation from multiple people SRT at < 0.1 should not be a problem with insurance. Looking at some graphs of studies showing PSA progression in cases of BCR after RP, if one is undetectable < = 0.03 the first year, although of course it varies between individuals, getting to 0.1 let alone 0.2 is very very unlikely going to happen in a year. Even at very short 4-month doubling time, for one year. a 0.02 would only end up at 0.08 after a year. So suffice to say, I've got a long time to think about things even if it comes to that.

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Replies to "There's some more recent studies that show going before 0.2 has statistically better outcomes. Strangely one..."

I find this discussion very relevant.
My most recent PSA was 0.08 on 1/5/2024. It was at 0.02 four weeks earlier 12/11/2023.
It was < 0.01 on 8/28/2023 when I just finished a 6 month clinical trial using Orgovyx and Erleada (with five rounds of radiation to a metastasis to a lymph node in my chest half way thru).
RRP was 3/25/2021. PSA 11.6
Post surgery lowest PSA was 0.37.
On 9/9/2021 PSA was 0.69 stared 34 rounds of Salvage radiation 9/27/2021.
On 12/10/2021 PSA was up to 1.29.
I was on active surveillance for the next 12 months until PET/CT found the metastatic lymph node in my chest. That is when I got into the METACURE trial.
My oncologist said that at 0.08 nothing would show up on a scan. My next PET/CT is in 8 weeks. So it looks like more treatments or trails are on the horizon for me...