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Anyone experienced Bone Marrow Transplant with TP53 mutation?
Bone Marrow Transplant (BMT) & CAR-T Cell Therapy | Last Active: May 9 4:42pm | Replies (20)Comment receiving replies
Hi katgob,
I'm certainly not one to diagnose your situation. But, I will tell you that City of Hope is one of the finest institutions for Bone Marrow Transplants. I probably would have gone there, but Cedars Sinai, another fine institute, is closer to my home. My disease was Myelofibrosis, one of the many blood cancers. I had my BMT on October 13. Unfortunately, I had a few unexpected complications and was in the hospital 38 days. I've now been home 5 or so weeks. My blood counts are slowly moving in the right direction, but the scaring from Myelofibrosis makes the stem cell engraftment a slower process. I am fortunate to have a good support group around me that continue to offer prayers and words of encouragement. As for TP53, doctors at both Cedars Sinai and City of Hope told me months ago that there is no current treatment for TP53. I haven't asked my doctor about TP53, since I had my transplant. I'm focusing on my recovery. My next bone marrow biopsy will be in about 30 days. At that time I'm sure I'll find out if TP53 is a factor. BTW...things are advancing rapidly in cancer research and City of Hope is the right place for new advancements.
A great resource on the internet is Be The Match. They provide all sorts of support for Bone Marrow/Stem Cell transplants. They are also the national registry for stem cell donors. You will most likely get your donor from there.
Best of luck as you move forward!
Replies to "Hi katgob, I'm certainly not one to diagnose your situation. But, I will tell you that..."
Hi Steve, I just wanted to check in with you to see how you’re doing after your transplant. It’s been a couple of months so I hope you’re starting to have some energy returning, along with an appetite. ☺️
You should have had another bmb and chimerism run by now. Always a little anxiety when waiting for that result! How are your numbers?
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Steve,
Thank you for replying. I agree about COH. My medical oncologist moved to Cedars as my active treatment ended last year, I was looking to keep her just in case for the future. This new diagnosis was because I was concerned about my low platelet numbers. I have a blood clot, so the Dr. I saw for that was who get to me to the hematologist.
The Hematology doctor said it was good i was there. My TP53 is at 2%. There are no blasts or any sign I have progressed. He wants the transplant before I get the leukemia. I need to ask him which one i may get. In December, the Doctor at COH said they have a few matches from the registry. I will have another blood test in early February to see where i am at in numbers.
I asked him about Be A Match and he said I do not need it. City of Hope is there for me.
I appreciate you posting as i read your journey and wondered how you are doing.