I had a port implanted with my second lumpectomy when it was decided that I needed chemo. I didn't have pain but rather just mild discomfort barely noticeable. The port was located near my heart (left side) and for some reason its position was awkward at night as I sleep on that side. It only bothered me a few days until it or my body adjusted. Do make sure to get the lidocaine cream or a numbing spray before each infusion. I tried going without once, and the pain was fierce and lasted 20 minutes or more. A month after I finished chemo (to allow your immune system time to recover) my surgeon removed the port at his office with just a local (needle) anesthetic. Again, just minimal discomfort.