← Return to Improve bone density and strength without medication?

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@gently


Tymlos has a greater attachment to parathyroid receptors called RG conformation. This attachment leads to rapid and swift increase in intermittant signaling. Forteo binds weakly to RG but more firmly to RO receptor which results in prolonged signaling of cells and prolonged calcemic responses. Intermittant signaling results in greated bone growth. Prolonged signaling supports resorptive action.
One other piece of on line information:
bioavailability of 80mcg Tymlos 36mc
bioavailability of 20mcg Forteo 19mcg
Some really smart person could volunteer to straighten all this out.

I wonder if reduced dose of Tymlos provides a greater percentage of bioavailable abloparatide.
With the RG advantage Tymlos must have a wider anabolic window than Forteo by far.

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Replies to "Tymlos has a greater attachment to parathyroid receptors called RG conformation. This attachment leads to rapid..."

@gently great info, very helpful! I do think it is oversimplifying to say Forteo is 1/4 the strength of Tymlos in order to justify two clicks, but I am not knowledgeable enough to figure it out! Your post was really helpful. I guess docs are telling patients that two clicks are enough but it would scare me. Even I, who was in the ER after my first full dose, managed over time to get up to 6 or 7 clicks. The side effects are new with each bump up but then they settle down, in my experience. With your research, what do you think?