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Improve bone density and strength without medication?

Osteoporosis & Bone Health | Last Active: Jun 6 11:28am | Replies (177)
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@windyshores

I wonder if the dose difference between Forteo and Tymlos is due to the differences in how they work. (see below) Perhaps Forteo is more direct. When they gave me Forteo in the office I had to stay there for 90 minutes because I could barely breathe, I was dizzy and my heart raced. I chose Tymlos ultimately (It was not available when I tried Forteo) because the pen is adjustable. I started at 2 clicks and moved up slowly. There are 8 clicks in a full dose and I had excellent gains on 6-7 clicks.

One piece of info online:
"Forteo is a lab-made version of human parathyroid hormone (PTH) and Tymlos is a version of human parathyroid hormone-protein. These two drugs are both similar to the PTH that your body produces naturally."

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Replies to "I wonder if the dose difference between Forteo and Tymlos is due to the differences in..."
gently | @gently | Dec 23, 2023


Tymlos has a greater attachment to parathyroid receptors called RG conformation. This attachment leads to rapid and swift increase in intermittant signaling. Forteo binds weakly to RG but more firmly to RO receptor which results in prolonged signaling of cells and prolonged calcemic responses. Intermittant signaling results in greated bone growth. Prolonged signaling supports resorptive action.
One other piece of on line information:
bioavailability of 80mcg Tymlos 36mc
bioavailability of 20mcg Forteo 19mcg
Some really smart person could volunteer to straighten all this out.

I wonder if reduced dose of Tymlos provides a greater percentage of bioavailable abloparatide.
With the RG advantage Tymlos must have a wider anabolic window than Forteo by far.

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gently | @gently | Dec 23, 2023

Did you have any testing during that 90 minutes. EKG or blood pressure. Thank goodness you had it in the office. I wonder if it was drug induced hypercalcemia, which could be why the lower clicks were better for you. This clicking business has been of great benefit. I'm always tempted to ventriloquize.

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