I’ve been on Tymlos since June. The 1st month I was on the full dose and had unmanageable headaches and low back pain. So, I dialed down to 6 clicks and worked my way back up to 8 clicks. I still have occasional low back pain. As stated the b/p drop, palpitations and headache occur very soon after the injection. I take the medication in the evening to better manage the side effects