Hi Gently, I take D3 & MK2 4 mostly a couple of times a week. Never multiple times in a day. I have extreme food and chemical sensitivities and typically react to both D3 and K2. If my reactions are worse I take them less often. Sometimes I stop so that I won't be reacting to them and can try to figure out what else I'm reacting to. Sometimes I try to see if summer sun is enough to keep my D3 levels up (it never is). If my D goes down I try to get it back up. I'm shooting for the 50 ng/ml range based on a variety of "expert" opinions and guesses. Basically I have to experiment and ab lib my way around taking any supplements or foods for that matter. Which is probably why I have osteoporosis. I was on an extreme low calcium "diet" (unintentionally) for many many years. BTW, good researching on your part to find this info. I'd never heard of this in relation to D.

MK-4 caused my Lipoprotein a to rise, so I stopped taking it. I’m waiting to try MK-7, which is supposed to do the opposite. Tried DIM with my hormones and it elevated blood pressure. We have to be careful with supplements, too.