Thank you, @wurd, for your response to my earlier post. I'm surprised and sorry that, after 18 years, your neuropathy came back to make your life more painful and difficult. I have read, again and again, that the side effects of chemo and radiation can recur months and years after treatment stops. I finished my chemoradiation (6 cisplatin infusions and 33 pelvic radiation treatments) for vaginal cancer in June and am finally feeling what I consider to be my new normal. I will see my gyn-onc every 3 months for 2 years and my gyn radiologist every 6 months. I have been very lucky that, so far, my side effects have been "as expected" and, on the whole, I tolerated treatments well. However, the awareness and fear of neuropathy and, of course, recurrence of the cancer, is always with me. After 18 years, you could rightly think you were out of the cancer side effect woods. Of course you feel depressed and blindsided by this unexpected late effect. I hope your team at Mayo will suggest treatments that can improve your quality of life and relieve your pain. I will hold you in my thoughts and I agree with your hope for kinder, gentler, more affordable cancer treatments going forward.