I am barely over 100 lbs with bronchietasis MAC and exacerbations. I am not on the big 3 meds. I am supposed to also use the hillrom vest twice a day and nebulize. I am very unmotivated to use the vest as it causes back ache. Instead I use an acapella device and NAC supplements. This seems to have helped me in the summer months although now I am having exacerbations requiring antibiotic .