I began my RA journey as seronegative, and questionable as to whether it was PMR because of my initial and very acute onse of pain and dysfunction in shoulders, hips, ankles and hands.
I was put on Humira and methotrexate in my brand new Rheumatologist’s office and had massive relief in 5 days. I’ve had to change biologic 3 times and abandon methotrexate due to liver impact , but I’ve stayed fairly well controlled. And three years ago I was retested for RA factor and it was extremely high. Go figure.