Yes, there is a definite side effect of losing sexual interest. I did not know it while I was on over the years several of them. Some (anti-depressants) have more of an effect than others. I will say that I have been on Welbutrin XL and Lexapro and there were the sexual side effects, disinterest, no shall we say passion or intensity. Along with the side effects of seizures with an increase in Welbutrin XL, I managed to stop taking Welbutrin XL and weaned off Lexapro. We each have to weigh what is important to us, our mental wellness if the anti-depressant works, or our sexual effectiveness for our emotional and physical well-being.