I think insurance companies prefer Docetaxel versus Jevtana when Castrate Sensitive. At least that is what I have been told. Jevtana also seems to have fewer side effects and is better tolerated. My understanding is that for some who become Castrate Resistant doctors may choose a combination of Jevtana and Carboplatin. My understanding regarding Pluvicto is that people respond in three ways. 1) It does not work. 2) It works but only drops PSA 50%, or 3) there is a profound response to the treatment. I do not know why Pluvicto works for some and not others. I have the same questions about chemotherapy and ADT. I'm guessing it depends on the type of PC mutation that one is experiencing. Is there BRAC1 or BRAC2 involvement or some other mutation that one might not be aware they have. Prostate Cancer sucks. We have to keep fighting.