Has anyone had any experiences with Otezla? I will be starting on it as soon as my government (Ontario) plan approves it for my scalp psoriasis. Been on two biologics before - first, Stelara and the Skyrizi - and neither helped. I asked to go on Otezla because I was tired of injections and because it seems lesser of all evils where side effects are concerned. It also can be taken orally. I have fatty liver disease and unfortunately there is no oral medication I can take that won’t affect my liver.

I was on Methotrexate for about three or four years and it worked great - cleared all psoriasis - but I was told I couldn’t continue taking it because of my FLD history. As soon as I started tapering off it, my psoriasis returned, then returned with a vengeance once I came off Methotrexate completely. I went on the biologics (first Stelara, then Skyrizi) and they have done nothing for me. I also have Lichen Planus and Lichen Sclerosis, and apparently Otezla clears that also, which is why I chose to go on this biologic, but I still am worried about the other side effects.