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How long do Lupron side effects last after treatment concludes?

Prostate Cancer | Last Active: Jul 22 9:09pm | Replies (66)
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@mauinokaoi

I am 76 yrs old. I had a robotic prostatectomy in 2006, and doctor reported prostate was fully encapsulated. In late 2016, I had a biochemical recurrence, and began Lupron and Casodex in Feb 2017. I have been on this treatment continuously since, with one treatment holiday beginning Nov 2021 and lasting for two years, taking only the Casodex. I have had two monthly Lupron injections beginning Nov. A different oncologist suggested Orgovyx rather than Lupron, but I see no benefit since my testosterone is already now low and my psa below 1.0 and dropping still. I have learned to tolerate the side effects as the price to pay for keeping the cancer at bay. The injection is just a nuisance. Can anyone suggest a good reason why Orgovyx is somehow superior to Lupron in terms of their effectiveness?

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Replies to "I am 76 yrs old. I had a robotic prostatectomy in 2006, and doctor reported prostate..."
Colleen Young, Connect Director | @colleenyoung | Dec 19, 2023

Good question, @mauinokaoi. I wonder if you might get an answer from the guys talking in this discussion:
- What's your experience with Orgovyx (relugolix)?
https://connect.mayoclinic.org/discussion/the-orgovyx-thread/

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gently | @gently | Dec 20, 2023

mauinokaoi,
I'm replying with the orgovxy site because it shows you a timeline with testosterone supression between the two lupron and orgovyx. Orgovyx provides a more steady dose because you take it everyday. We don't know what the psa does between lab draws, I assume it rises and falls with the testosterone levels.
I know far less than you do about all this. https://www.orgovyxhcp.com/efficacy/

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michaelcharles | @michaelcharles | Jan 8 8:34am

Layman opinion: Stay with the devil you know.
I took Orgovyx for 4 mos as part of my salvage radiation w/ ADT tx.
If your side effects (SEs) are manageable for you, I would be inclined to stay the course.
It sounds as if you restarted Lupron in Nov 23.
If you are on holiday again, you could try Orgovyx.
However it may cost you significantly more because it is covered under Part D Medicare as opposed to the coverage for injectables under Part B Medicare.
My Part D coinsurance
cost was 25% or about $ 1000 / mo for Orgovyx until I reached the catastrophic stage ( after 4/5 mos, but I cannot explain the math).
Best wishes for good results.

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