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Low WBC and MCTD

Autoimmune Diseases | Last Active: Dec 18, 2023 | Replies (19)

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@dadcue

The conditions mentioned in the posts above all fall under the umbrella of seronegative spondyloarthropathies. By definition, these diseases do not have circulating rheumatoid factor, hence the term seronegative. Psoriatic arthritis and reactive arthritis are just two of the conditions. There are several more.

These conditions have "overlapping symptoms" which makes them difficult to differentiate. The thing with the various types of spondyloarthritis is that you can have the characteristics of all of them. The diagnostic label is given according to what symptom predominates.
https://spondylitis.org/spondylitis-plus/an-updated-overview-of-spondyloarthritis-a-family-of-related-diseases/
The following link also has some good information.

If you scroll down you will see a picture diagram that is colorful.
https://boneandspine.com/seronegative-spondyloarthropathies/
The picture is referred to as the "famous venn diagram of spondyloarthritis." The names of the disorders are misleading because it is hard to see how connected they are by looking at the names only.

I'm surprised your doctor tested for HLA-B27. They seem to be on the right track. Unfortunately, being HLA-B27 positive doesn't confirm anything.

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Replies to "The conditions mentioned in the posts above all fall under the umbrella of seronegative spondyloarthropathies. By..."

Thank you!!

What a rubic cube of a diagnosis.

You know my son who had reactive arthritis following knee surgery has had a persistent issue with multiple levels of cervical and thoracic spine. He has two artificial discs and multiple levels of fusion. He had one really scary episode of infection he was hospitalized for after a fusion - the infection was sitting on the artificial disc - which of course has no circulatory system, and therefore won’t respond to it antibiotics. They had to go back in to essentially wash down the device with antibiotics

I’m now wondering if all of that may not be related to the reactive arthritis of years earlier.