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CA 27-29 numbers rising: Does anyone else have an issue like this?

Breast Cancer | Last Active: Aug 16 10:03am | Replies (176)
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@cchappy22

Hi. I’m new to this site. I had lumpectomy 10 years ago and radiation. For the first 5 years my CA 25-27 tumor markers were all in normal range then they started going up to 50’s and 60’s. My oncologist was testing me on a regular basis and sent me in for PET scan during this time. Nothing showed up. A couple years later I was diagnosed with Rheumatoid Arthritis. One time I was having an RA flare up and my CA 25-27 number shot up to 105. Went down after flare up cleared. I now have my RA medicine working pretty well and flare ups only happen rarely. Now My tumor marker tests have been two in the normal range and the others 40. Have other people had a similar experience?

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Replies to "Hi. I’m new to this site. I had lumpectomy 10 years ago and radiation. For the..."
Colleen Young, Connect Director | @colleenyoung | Dec 18, 2023

Welcome, @cchappy22. I'm tagging fellow members @sheilaray @kstar077 @renunciate @kensiejames, who have also mentioned they are breast cancer survivors living with rheumatoid arthritis (RA). They may also have experience with wonky tumor marker results.

I also found these research paper that talk about tumor markers and RA:
- Tumor markers are elevated in patients with rheumatoid arthritis and do not indicate presence of cancer https://pubmed.ncbi.nlm.nih.gov/22462421/
- Serum Tumor Marker Levels in Rheumatoid Arthritis https://jag.journalagent.com/aot/pdfs/AOT_49_3_237_242.pdf

I'd be interested to hear if your cancer team suggests a different monitoring test for you. I can imagine getting the results of elevated CA 25-27 is nerve-wracking.

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