I was first diagnosed and had surgery in 2015. We thought we got it all, but a year later my PSA rose and I underwent a similar protocol as you, ( Lupron, radiation, 2 years of casodex) in 2016-17. In 2018 my cancer returned ( PSA increasing) several times and I was able to successfully supress it with Intermittent treatments of Lupron and casodex treatment for three months. The first time my PSA dropped for 14 months, then started to rise and we treated again. The second and third times i got 9 months and then 6 months of supression. Now my PSA has again risen and my cancer has been diagnosed as CRT ( castration resistant cancer) and I am moving from intermittent treatment to continuous treatment of Lupron every three months. My side effects are minimal, with some tiredness and hot flashes mostly in the middle of the night, but certainly tolerable. We are now looking at some new drugs and a possible trial. However, when first diagnosed they thought I might live 2-3 years without surgery. I am now entering my 10th year, and with the new drugs available, we are relatively hopeful for another 5+, or maybe even 10. I will be 70 in three weeks, so this is actually more than I had expected, and grateful for every day. No question that this cancer is complicated and at times a bit debilitating, but there is certainly a life worth living with it as well.