I agree to watch and wait. I made the mistake of listening to my first respirologist who, I’m sure, had never had a patient with MAC before me. I naively followed his recommendation for taking the Big 3 when I should have watched and waited. I took the meds for 6 months before I got side effects and my bacteria load was higher after 6 months than it was when I started. I found a new respirologist and have been diligently doing airway clearance for over 4 years, with Mac better controlled than it was on the meds.

I’m not saying that medication is not the way to go for everyone but wait until you really need them (and with, any luck, until some of the drugs currently in development are available.