@maradeur Tymlos raises calcium levels briefly ( a few hours). But many of us never tolerate a full dose. After two years I still can't, though I can tolerate 7 clicks out of 8 on the pen. I suggest you go down on your dose to 4 clicks (half dose, which is still therapeutic) and move the dose up until you reach the highest level you can tolerate. There may still be side effects but it is possible to reach a point that is very tolerable while still effective. You could also try just dropping to 7 clicks! I had a 20% gain, from severe to borderline osteoporosis, using 6-7 clicks most of the time. Everyone is different but worth a try. Make sure to tell your doc!