I just came off ADT (Lupron & Abiraterone) a week ago after 18 months. I'm not sure what, if anything, I was expecting right away, but my fatigue, anxiety, and depression kicked up this week. After reading the other comments, it appears the side effects of no-T and Lupron are still clear and present. I will say, though, that while my hot flashes during treatment were minor and infrequent, they have really kicked up this past week-I'm more hot than ever and its winter in NY. Something kicked in my depression also, which came about related to cancer, radiation, and ADT- I had never felt it before being diagnosed and treated, or at least on this level. I had been feeling great for awhile (KAT), but things went sideways this week, a noticeable change in energy and drive. Will be #patient. Stay positive guys.