Hello @dragonspark,

I had the same reaction to 80 mg/day Tagrisso starting at about the same timeframe. In my case it did continue to spread to my back, chest, and face. It does present like a form of acne. Initially I was prescribed doxycycline (oral twice daily) along with a steroid cream and clindamycin gel. This helped a little but overall not much. My dose of Tagrisso was lowered to 40 mg and the condition improved after that however the acne persisted at a low annoying rate. A dermatology consult resulted in the doxycycline being replaced with cefadroxil and that was the miracle cure (I wished that was prescribed initially as it would have saved several months of dealing with this issue!). I recently tried to go back to 80 mg of Tagrisso but the acne came back after a week so the condition appears to dose related and my oncologist approved me going back down to 40 mg.

This skin reaction can be very distressing so I hope this helps!