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Need to start hormone therapy

Breast Cancer | Last Active: Dec 12, 2023 | Replies (5)

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@sarahmh

I understand! I’m 47 (diagnosed at 45, stage 2A, ER/PR+, HER2-, lumpectomy, chemo, radiation, and now hormone therapy). I started anastrozole and the Zoladex injection (it’s like Lupron). I have had zero problems from the Zoladex. The anastrozole (and letrozole) caused trigger finger, I switched to Tamoxifen, and Bam! I was walloped with sudden and severe anxiety and depression. Since there’s no official link between the two, I looked everywhere else for the cause/cure. Nothing helped until I asked in desperation to quit Tamoxifen, and Boom! the anxiety and depression very quickly lifted! (Side note, this link between anxiety/depression and Tamoxifen is pretty much denied by the docs, but way too common to be coincidence. I also think it’s more common in younger women.) I’m currently on exemestane and Zoladex with no problems at all, thank the Lord! I also take Verzenio, which causes mild diarrhea. Here’s my two cents for your situation; don’t let them rush you. It is important to reduce estrogen as much as possible to reduce risk of recurrence. Since you are pre-menopausal, the Lupron injections will “shut down” your ovaries, thus eliminating most estrogen production; my onc also offered removal of my ovaries as an option, so ask about that if it sounds preferable to you. The injections have been great for me. Then Tamoxifen or an AI will further help reduce estrogen. My onc strongly prefers AIs because they seem to be more effective at reducing recurrence. I would be very leery of Tamoxifen in your case; a younger friend and I both had anxiety/depression caused or exacerbated by Tamoxifen. If you are worried about the side effects of an AI, you can always switch if they are a problem (two didn’t work for me, the third did!) It’s wild that these drugs affect people so differently. Anyway, I’m always long-winded on this topic. So many people advised me to “advocate for myself” and it’s so true. Ask a million questions and speak up if something doesn’t feel right. Hugs to you all.

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Replies to "I understand! I’m 47 (diagnosed at 45, stage 2A, ER/PR+, HER2-, lumpectomy, chemo, radiation, and now..."

I will say this. Some of the drug manufacturers have different chemicals in the same pill. If you happen to ask your doctors see which manufacturer has the pills and pharmacy. They are all differently made. Some people take generic and some need the real medicine not generic kind. Just a thought if your pill is not working the best try a different pharmacy.