While I had surgery for my cancer I would like to share my experience with TRT. I experienced fatigue for years prior to my surgery. I had low B-12 which requires monthly injections. Extremely helpful but I still had some fatigue after surgery. Went to my wife's Internist who diagnosed my low T. Like the original poster, I was told I need to have undetectable PSA for two years after surgery before I can have TRT. I'm one of those people who has to know "why" whenever I'm told something. I read many studies that support TRT does not cause BCR. Went back to my Urologist who agreed and prescribed me daily T injections. They became too intense for me so I went to an Endocrinologist for further testing. He also agreed TRT does not cause BCR. He put me on Androgel which works great for me. I believe many Doctors stick with what they were taught years ago and aren't informed with newer studies. My post-operative biopsy showed high risk for BCR with EPE+ and SM+. I am very comfortable taking TRT and my PSA remains undetectable three years after surgery.