(previous post continued)

As you've probably already learned, about 80% of people diagnosed with PC catch it too late to even have surgery, so the fact your husband's was caught at this stage is still a good sign. What I learned later, that about 80% of the people who have surgery will still have a recurrence, and about 80% of those who do will have it in the first two years after surgery. So in a way, despite my initial (uninformed) hope, I was still likely (as most surgical patients are) to be facing the beast again. That was a late reality check; small consolation, but as it led me to this forum and a lot of the long-term survivors here, I do find encouragement and hope there will be some kind of cure for me before it's too late.

With all that said, I'm definitely not qualified to speculate on chances of survival, but I can offer hope. I've been on the "less effective" chemo (Gemcitabine + Abraxane + Cisplatin) for 10 months now. My main tumor and all the little mets in my abdomen have either stabilized or shrunk slightly. My CA19-9 has come down from almost 700 to low 40's. I feel no ill effects I can attribute to cancer (other than some depression), and only mild effects (neuropathy, fatigue, and difficulty focusing on work, which I'm still doing full time) from the chemo. I haven't paid for a haircut all year either. All a fair trade, IMHO, given the circumstances!

I'm going to suggest 5 trials your husband might be able to participate in, but those are just a fraction of what's out there. PanCan.org and CancerCommons.org might be able to help you find others that are appropriate to any specific mutations your husband has.

1) Basecamp + Everest: (CAR-T cell treatment)
Basecamp-1: https://clinicaltrials.gov/study/NCT04981119 , which would determine eligibility for
Everest-2: https://classic.clinicaltrials.gov/ct2/show/NCT06051695

2) Natural Killer cells: Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer ( NCT05922930 )
https://clinicaltrials.gov/study/NCT05922930
(Might be appropriate if there's any evidence of spread in the peritoneum)

3) Targeting Claudin 18.2 with CAR-T cells (CT041)
https://clinicaltrials.gov/study/NCT04404595

4) Targeting Claudin 18.2 with T cell-engaging bispecific antibody (AZD5863 )
https://clinicaltrials.gov/study/NCT06005493

5) Conventional chemo (GAC) plus Tumor Treatment Fields (Mayo Jacksonville only)
https://clinicaltrials.gov/study/NCT04605913

As mentioned earlier, ask your medical team, PanCan.org, CancerCommons.org, and anyone else you can find for help __ASAP__ navigating the clinical trials landscape and expert second opinion options before you get locked into a traditional treatment that might not be optimal for YOUR particular case. Remember, they're treating YOU (your loved one), not just the statistical-median patient.

Wishing you the best!!!

--mm