It's interesting, mainstream thinking that TRT is a non-starter for someone who is coming off treatment yet if it returns gradually and naturally, that's "ok." That's my perception 10 years into this journey. That thinking is used to advise men to stay on ADT permanently or at least until you become castrate resistant then...

You can search for intermittent versus continuous ADT, you'll find a variety of clinical data, yes or no. Overall I think that data says there may be some slight difference in overall survival. There is also data about the time off shortening with each vacation.

I'm a layman like everyone else so take my thoughts in that context. Here's my clinical history...note that my T began to return in Oct 18 (135) which would have been three months after the last 90 day Lupron shot "wore off."

By February 2019 it was 400+ and finally in April 2023, 600+. Yet from that time in October 17 to roughly the end of December 2022, my PCa stayed "quiet." Why, if T is the fuel then somewhere between Oct 17 and Feb 19 it should have reared its ugly head.

I am a study of one, no way to clone myself and see how other treatments turned out, just the results of the one I chose.

So, in MY case, T recovered naturally with no affect on PCa until almost 4-1/2 years. Would it have been different with TRT, I don't know!

If your decision in conjunction with your medical team is TRT, then active monitoring, labs and consults every three months or so to check PSA and T should be strongly considered. That may give you the clinical data to determine if and when your PCa rears its ugly head and then you have decisions to make.

Kevin