My Humana insurance denied the charges for Signatera, however, Natera, the company that makes Signatera, stated to me that they will make every attempt to collect from insurance. Since Signatera is new, it is not on the list of approved tests with Humana. They also said if insurance still denies that patients are not expected to pay charges. Sounds like they are going to take care of it somehow. Ill try to remember to post when I find out more. Whether the test is beneficial or not is yet to be seen, but I figure why not go ahead and gather some information during the process.