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Multiparametric MRI (mpMRI) over diagnosis?

Prostate Cancer | Last Active: Dec 14, 2023 | Replies (32)

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@pablo81

Primary reason I have resisted is concern over spread if the lesion is cancer because of invasive nature of the biopsy.....

Literature says to monitor via another MRI in 2 years to check if growing. I had a second MRI at 13 months which showed no growth.

Also most recent PSA Free test suggests that "if" it is cancer it likely is not aggressive. Everything seems to be "if" or "maybe"..

Why was MRI ordered? Because I had a PSA of 4.3.... Later I learned that 4.3 is not high for my age.

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Replies to "Primary reason I have resisted is concern over spread if the lesion is cancer because of..."

I agree. It’s been 7 weeks since my biopsy and I’m not yet 100% back with full sexual function. I was never told about this issue…I am a very healthy 67 year old, taking no medications, so there is no reason for this issue…except the fact that I had a biopsy.

I felt rushed into getting a biopsy because my mpMRI indicated there were PIRAD 4 and PIRAD 5 level lesions.

It turned out that all they found, in those targeted mpMRI lesion areas, were 3 + 3 Gleason cancer cells; which are known to NEVER metastasize.

I was one whose mpMRI was overdosed. Apparently that can happen as much as 75% of the time with those told they have a PIRAD 5 lesion (even from the very best radiological mpMRI reading laboratories), depending on the radiologist who reads your mpMRI scan, according to Dr. Matt Cooperberg (UCSF), a prostate cancer specialist.

My urologist could not answer this question, when I posed it afterwards…so I had to find the answer through my research.

I decided to go AS…and I will be very reluctant to undergo another biopsy, unless my PSA spikes through the roof AND I get 2nd and 3rd opinions on a subsequent mpMRI that CONFIRM lesions which are definitely PIRAD 5.

All that said, I have significantly changed my diet and increased my running to 10 miles per week.

I don’t expect any more problems with my PCa, based on everything I’ve studied about men who have received a similar PCa diagnosis AND have taken the subsequent actions that I have now implemented.