This is fascinating to me. I began my treatment with Humira and methotrexate and it worked until the mtx caused elevated liver enzymes. When we reduced mtx, I developed antibodies to Humira and had to switch to Enbrel. That worked well for 2 yrs and then it didn’t. So I was switched to Remicade infusions and they are still working well.

Today there a lot of biologic options for RA. It’s curious that a condition so closely related isn’t relieved by them.

I try to power through flares because I want to reserve prednisone for urgent situations. Thankfully they’re uncommon for me. But when they come I watch it unfold from distal joints to more proximal and larger ones and in 10-14 days it’s usually done.