Hi @stacie16. I have the same three diagnosis that you have. Pseudomonas A. is a constant with me--5 years now. It will get worse, then better--repeat. I've been on Tobramycin off and on these 5 years. Am waiting now on the results of latest sputum that will let me know the current status of MAC. My Pseudomonas check was positive. This past March I was at a point of desperation. I was taken off the Toby, stopped the inhaled saline for 3 days and given two weeks of Cipro. I had a "?fixed drug eruption" from the 750 mg of Cipro and it was reduced to 500 mg. I just kept taking it through to the end of the 14 days. The turnaround was glorious. Within a week I was soooo much better. Now, life is, for the most part, normal again. I have found that I cannot ignore my twice a day air way clearance or the pseudo worsens. This is a small price to pay to get quality of life back. Always remember, everyone is different. God Bless.