I started getting neuropathy in my feet after cycle 5 or 6. I first noticed tingling in my fingers a couple of cycles later. After cycle 8 it got worse in both hands and feet. It would subside somewhat before the next cycle. I haven’t had any pain but now the numbness is constant. They dropped the oxaliplatin after cycle 10. The last two cycles were irinotecan and 5FU. I have read and the oncologist agreed that it may get worse over the next month or two before it hopefully starts to subside. I’m two weeks out from cycle 12 and starting to feel back to normal with the exception of the neuropathy. I try and exercise regularly. Hoping that I’m one of the lucky ones that experience diminishing neuropathy over time. All the best to your husband as he goes forward. It’s a grind but hoping it’s worth it.