Hi, I started the big 3 in October. I take the azithromycin on empty stomach two hours before breakfast. Around noon I take the ethambutol with lunch. Two hours before or after dinner (empty stomach) I take the rifampin. So far so good. I only take on MWF. Best of luck! I also eat yogurt and take probiotics on the days I don’t take the meds.

Hi!
In my case I was given Azith and Ethmbutol as a pair because the Rifampin interacted with my chemo treatments. Once Chemo was over, I started all 3 together which I take at night with no major side effects. Fatigue and a weakness in my legs at times but nothing that prevents me from living my life.
However, I had to drop out of playing competitive sports.
After 6 months (MAC) was still positive and I was approved for Arikayce and continued with the same regimen Big 3 three times p/w. After 2 months on Arikayce, I' had a negative sputum culture so I'm on the right path and once I have had 3 or more negative cultures, I will be weaned off the drugs.

I have been in the big 3 since August 23. I was told I could take together or not. I started taking all three at night … 2-2-1/2 hrs after good. So close to bedtime. I’ve no problems at all. I was prepared for some sort of reaction to something… but pleasantly surprised. MWF between 8-10 pm. I didn’t start taking any meds until the second CT showed the bacteria increasing. So, 6 months down…18 to go! Can’t wait for that first glass of celebratory wine! Good luck!