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Undecided choice of drugs for Osteoporosis

Osteoporosis & Bone Health | Last Active: Sep 8 8:12am | Replies (393)
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@windyshores

@sallyj2 I had a 9% gain in hip and 20% gain in spine. Many side effects go away after a few weeks. I minimized mine by ramping up slowly and doing whatever dose I could tolerate, which ended up being 7 out of 8 clicks for much of the time. If I had something important to do on a given day I did less. Exercise was not only possible, but, for me, it helped with side effects. I felt worse if I stayed in bed. I did it in the morning and for me, side effects were better that way.

@cat714 Evenity was very new when I started Tymlos two and a half years ago. I did a masterclass with Dr. Lani Simpson who mentioned the sequence issue. The only think I have read is that Evenity "turbocharges" growth so there is less left for Tymlos to do. I also wonder if the anti-resorptive effects of Evenity reduce the effectiveness of Tymlos (similarly to bisphosphonates and Prolia). You can try Tymlos after Evenity and do blood tests- CTX and P1NP- and let us know if it is working for you!!

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Replies to "@sallyj2 I had a 9% gain in hip and 20% gain in spine. Many side effects..."
cat714 | @cat714 | Dec 3, 2023

I'm waiting for an appointment with endo. I will be finished with evenity in April. My interest I tylmos is coz of click size till body is used to it & I've read that dentist don't have problems with it. I will report back when I see her

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gently | @gently | Dec 3, 2023

Thanks, windyshores. I couldn't find a source for the idea that Evenity shouldn't be followed by Forteo. I wonder if that sequence issue is still held. Since the first 3 months are turbocharced growth and the last 9 antiresorptive. (You are probably my souce for both ideas.) Following the antiresorptive 9 months with Forteo or Tymlos would, then, be ideal.

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mayblin | @mayblin | Dec 3, 2023

@windyshores while I'm very envious of your remarkable results, I'm truly very happy for you!

Do you mind sharing your tbs results before and after treatment? Does your doctor use bone turnover markers to monitor treatment progress, as well as using them to direct future treatment plans?

What treatment(s) did you have before tymlos, if any? Im especially intersted to hear whether or not you had past bisphosphalate treatment(s). Have you decided with your physicain what's next after tymlos?

I'm using forteo right now. Although forteo and tymlos are similar analogs of pth, one thing strikes me is their dosing difference. It looked like forteo manufacturer had 20, 40, 80 mcg tested, using 20mcg as their marked product indicates higher dosing may not offer much upside, or they'd like to avoid unforeseen severe side effects with higher dosing after market. After all, forteo is the pioneer as anabolic therapy. Did you know if effects of tymlos on bone building is dose dependent, ie, higher dose produces more bone growth? If so, then tymlos would be a better anabolic choice, considering other factors being equal?

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