I can't speak to radiation side effects. I haven't had radiation for pancan. I did have 16 rounds for a small DCIS (breast cancer) in winter 2022-23, but had no side effects. Re the neuropathy, have you talked to your MD about gabapentin? It is often prescribed to help with neuropathy. I've never taken it, so I don't know how effective it is or whether it has side effects as well. But it might be worth asking about. Another option might be discontinuing the oxaliplatin for a little while to give the nerves a chance to recuperate. That raises other questions of chemo effectiveness, so be sure to discuss this with your MD and weigh the options.

Re appetite, that's a tough one no matter what type of pancan treatment is being administered. In general, I've found smaller meals, more frequently, suit me better. In my early chemo days, when I was really struggling with loss of appetite and stomach upset, I relied a lot on bland, starchy foods, such as baked potatoes, rice, bread. Be sure that your relative stays hydrated. I never was able to manage sports drinks, but a lot of people on this board say they've had good success with them. Getting better nutrition and hydration should help with the fatigue, I hope.