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← Return to PMR flare at a drop from 8 to 7 mg of prednisone?
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PMR flare at a drop from 8 to 7 mg of prednisone?
Polymyalgia Rheumatica (PMR) | Last Active: Dec 2, 2023 | Replies (44)Comment receiving replies
Not being able to taper gracefully is a good way to describe it. There was nothing graceful about how I tapered---that's for sure.
Kevzara (sarilumab) was FDA approved for PMR in February of this year---2023.
https://www.the-rheumatologist.org/article/fda-approves-sarilumab-for-the-treatment-of-adults-with-glucocorticoid-resistant-pmr/#:~:text=On%20Feb
and
https://www.ajmc.com/view/sarilumab-indication-expanded-to-include-polymyalgia-rheumatica
I hope Kevzara works for you.
Actemra (tocilizumab) helped me taper off prednisone gracefully. Actemra is FDA approved for GCA.
Kevzara and Actemra target the same inflammation pathway.
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Methotrexate has been helpful to the tapering. That is until I hit 7mg of prednisone and now all helll has broken loose. Couldn’t walk over thanksgiving. My c reactive protein had gone down to normal over the last 9 months but SED remained in the 40s. Blood work this week shows c reactive protein now high and SED rate doubled. Very discouraging. Doc trying to get me on the Kevzara but approval is taking awhile. I’m hopeful but frustrated. Doc said two other patients were doing well with Kevzara. They too had proven “resistant to tapering.”