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Treatment for Prostate Cancer Metastasized to Bones

Prostate Cancer | Last Active: Feb 27 7:27am | Replies (146)

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@spino

Here is an article that overviews treatment strategies as well as describes the metastasis to the bones. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10000416/# (Baldessari et al, Bone Metastases and Health in Prostate Cancer: From Pathophysiology to Clinical Implications, March 2023).
If I correctly understand this article, the reality it describes is very sobering. The average overall survival rate is less than two years and the treatments increase survival by an average of 10-20%, or 2-5 months. Because bone health is the overall challenge for this stage, both the growth of the cancer and the deterioration of the bone mass (osteoporosis) are challenges, and to some extent they oppose each other--treatments for cancer may increase the fragility of the bones and treatments for bone deterioration may increase the cancer.
In situations like this asking how we are going to spend the remaining months of life is perhaps more important than how we are going to treat the cancer. Your medical team may not be well-equipped to address this issue with you.
If you prefer charts to words, look for the charts in the article. There are several that overview the course of the disease and the impact of available treatments.
While it is always possible that a clinic in Mexico has found strategies for disease management that no one else has or that a different MD will have a better treatment than our current MD, I am aware of no group of survivors who are saying ten years ago the scans identified bone metastases, but now it is no longer a problem for me. If you're in that group, please speak up?!
There is a stage where the biochemical markers identify that metastasis must be occurring but the bone tumors are not really evident yet. It is as this stage that most of the treatment strategies are trying to intervene in ways that extend the time it takes for the bone metastases to emerge.

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Replies to "Here is an article that overviews treatment strategies as well as describes the metastasis to the..."

I think that's a little harsh, and unnecessarily discouraging for people with newly-diagnosed bone-metastatic prostate cancer. It really depends on the number of metastases, and even then, there's huge benefit from introducing androgen-reception inhibitors like Apalutamide. I'm at 26 months now, with PSA still undetectable (< 0.01) — tested today — and no progression. I had the metastasis in my spine radiated, as well as the primary tumour in my prostate.

The TITAN study for metastatic, castrate-sensitive prostate cancer (using ADT and Apalutamide) did not even reach median overall survival at 52.2 months. Median overall survival with ADT and placebo was still almost 40 months.

Source: https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.6_suppl.11