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Oxaliplatin: What are the effects of dropping it from FOLFIRINOX?

Pancreatic Cancer | Last Active: Dec 4, 2023 | Replies (20)
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@jk77

@lisn, my response will be of limited use bc I had no problems with oxaliplatin -- but that might be bc I was always pre-medicated.

I was always pre-medicated with steroids (dextromethasone) before the infusion and I also took a dose on the morning of Day 2 and Day 3. (My pre-meds also included generic Zofran, for nausea.)

I was told to take one tablet of Claritin on Days 1 thru Day 5, and I did.

I also received, with infusions 2 thru 8, a shot of atropine along with the irinotecan, because without it I felt intense bowel urgency. Even with the atropine, the irinotecan hit me hard -- my eyelids twitched, I developed post-nasal drip, and by the final infusion I had a weird sensation of my legs being too heavy to move. ***All of these side effects dissipated within a few hours,*** but I'm mentioning them in case the info is of use.

Apologies for going slightly OT.

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Replies to "@lisn, my response will be of limited use bc I had no problems with oxaliplatin --..."
lisn | @lisn | Nov 30, 2023

Thank you for your response, I really appreciate it!
He has the same regime as you do with regard to the pre-meds and the steroids on days 2 and 3. That all started after the 3rd treatment where he had a reaction to the Oxaliplatin (fever). And just like you, he also gets the Atropine at each treatment with the same eye twitching during the Irinotecan. You both have such similar experiences!
I guess I'm just trying to gather some information on my own before we meet with the oncologist at the next treatment appointment in two weeks. My husband has had a very difficult time with side effects and reactions and side effects and reactions to the medications prescribed to treat the side effects! The team is aware of how sensitive he is. This experience yesterday was the most intense. I was hoping that they would just discontinue the Oxaliplatin altogether if it's something that they consider doing further down the line if neuropathy becomes an issue. If the efficacy is the same, I'd rather they stop it. My husband is concerned that having one less medication would not be the best case scenario. I guess we'll wait and see. I hope you're doing well.

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