Kevin, you summed it up perfectly for what I have experienced. My last Eligard injection was June 19, 2023 and the duration of its effects is supposed to last for 6 months which will be the 18 months of treatment the urologist wanted. I began 3 months before starting 39 sessions of Proton Beam therapy at MD Anderson. My question to you is when did you first notice the lessening of the hot flashes and night sweats of the 18 months of Lupron? I am assuming you had 3 injections spaced 6 months apart? The weight gain, (about 15 lbs.) and the day and night sweats have been the most bothersome of the side effects. Shrinkage and loss of libido, while on ADT is an effect, but I have not been bothered by it psychologically.