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Oxaliplatin: What are the effects of dropping it from FOLFIRINOX?

Pancreatic Cancer | Last Active: Dec 4, 2023 | Replies (20)
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@mnewland99

Hi markymark!
I missed what ATR inhibitors are. I'm still stage 2 as far as i know, but this could possibly be changing. I ask because I have some type of ATM mutation "of unknown significance" (or the translation might be that there just isn't enough scientific evidence right now to support that my mutation is directly related to pancreatic cancer (even though my dad had it, and his mother had breast cancer in her 40's). I'm feel I probably do have an ATM mutation, so I'm interested to know about ATR.

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Replies to "Hi markymark! I missed what ATR inhibitors are. I'm still stage 2 as far as i..."
markymarkfl | @markymarkfl | Nov 29, 2023

I confess I don't have the biochemistry background to comprehend it, much less explain it in plain English, so I'll just take a shot and recommend follow-up w/ someone competent.

ATM = ataxia-telangiectasia mutated
ATR = ataxia-telangiectasia and rad3-related

Both are proteins cancer cells call on to try and repair themselves when damage occurs to their DNA. ATR and ATM appear similar enough that one class of drugs (ATR Inhibitors) can work to prevent either mode of repair. Without repair, the cell will most likely die without reproducing.

There is a long list of ATRi drugs in the first column of Table 1 in this paper:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323102/
The table also lists other drugs (including PARP inhibitors) that the ATRi is being combined with.

I must repeat that I only understand 1% of what I typed above and offer no guarantee of accuracy.

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