Hello dragonspark, I’ve been on Tagrisso for a total of 8 months now (following my chemo treatments). I started at 80 mg/day for about 4 months however I was having such moderate skin reactions (acne-like) that they then lowered my dose to 40 mg. That really didn’t totally resolve the issue until they have switched the antibiotic treatment from doxycycline to cephadoxil (huge improvement!!). I haven’t noted any other adverse effects except for elevated creatinine levels which may be Tagrisso related.
I did a quick review of articles related to cancer cells being more active during our sleep cycles and it appears that there might be something to that. One problem that I could foresee is to remember to take your medication every night……sometimes I just want to get to bed as quickly as I can. I should note that each dose of Tagrisso also stays in your system for a few days (the half life….meaning 50% of the dose….is still in your system after 48 hours, so if you are taking a daily dose you are constantly being exposed to the drug). I hope this helps.