So, John, IF I am interpreting the medical jargon correctly, P5P is less likely to cause B6 Toxicity than Pyridoxine? My podiatrist put me on Metanx a month ago, and I was concerned since I saw that it contained B6 and I had read so much about B6 toxicity causing neuropathy. But I had just had my B6 plasma levels checked by my PCP and my B6 was at a very good spot. So I have been taking the Metanx, and it "seems" to be gradually making a difference. I understand it may take up to 3 months to feel the full effect. In the meantime, I am planning to have my B6 level re-checked after a few months.... just to reassure myself. This disorder is so complicated and each of us may react differently to the treatments offered ... with some, sadly, having no reaction at all. Thank you for sharing this information!! I am SO glad that I found this group! Mike