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PN from low dose b6

Neuropathy | Last Active: Nov 28, 2023 | Replies (16)

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@ray666

Hello, bb0753 (@bb0753)

You're probably already familiar with the difference between Pyridoxal 5 Phosphate (P5P), the active, water-soluble form of B6, and Pyridoxine Hydrochloride, the kind of B6 that occurs in food and supplements, and how each kind of B6 relates to our PN.

When my neurologist suggested I try a regimen of EB-N5, a medicinal food containing P5P, for my large fiber PN, I was at first alarmed––Was I about to overdose on B6? He and I discussed this at great length (and Connect moderator John sent me some easy-to-understand literature), putting my concerns to rest.

I've now been using EB-N5 for 150 days and, although I still have PN, my symptoms are manageable and do not seem to have progressed. Is that due to the EB-N5, entirely or partially? That's hard to say. However, when I saw your topic, I thought I'd at least mention this.

Cheers!
Ray (@ray666)

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Replies to "Hello, bb0753 (@bb0753) You're probably already familiar with the difference between Pyridoxal 5 Phosphate (P5P), the..."

Hi, Ray, Do you know if EB-N5 is the same recipe as Metanx? And do you still have the link to the information that John sent you regarding the difference in P5P and Pyridoxine Hydrochloride? Thanks! Mike

Yes Ray I'm familiar with research that shows the difference in the types of b6. However most multivitamins contain the b6 that causes neuropathy not the p5p b6. Also energy drinks and breakfast cereals and bars also contain the type that causes neuropathy. If the RDA for b6 is 1.3-1.5mg for most adults just imagine how many people may be experiencing idiopathic neuropathy from this synthetic b6. It is so easy to get the RDA of b6 from natural foods. I don't understand why the FDA allows this synthetic ingredient to be added to breakfast foods, energy drinks,protein drinks, ensure etc. None if these have p5p they have the synthetic b6. Many with idiopathic neuropathy may unknowingly feeding their neuropathy with multivitamins etc