I suffered from Chronic fatigue and brain fog. My rheummy recommended I get nutritional IVs. It is administered by a nurse in his office. When I say game changer I mean it. I went from a limp dish rag so to speak to a chatty Cathy and energizer bunny. Does not alleviate pain as far as I notice but gives me the energy and mental strength to over come the daily aches and pains. Seem to recover from flares faster too.