Replies to @johnbishop — John, what dosage of R-ALA do you now take on a daily basis? Leonard…

Discussion

Neuropathy | Last Active: Jun 13 6:09am | Replies (111)

Comment receiving replies

@njed

@johnbishop -- John, what dosage of R-ALA do you now take on a daily basis? Leonard (@jakedduck1) raised a good question. I am back and forth on the ALA and R-ALA, trying both at different times for 9 - 12 months at a time. I have tried both types, 600 mg. to 1200 mg. daily and can't determine if it helps. Odd thing is that neurologists have told me to try ALA and see if it helps. Neuro doc at Mayo did not say it. What helps one might not help someone else.

Jump to this post

Replies to "@johnbishop -- John, what dosage of R-ALA do you now take on a daily basis? Leonard..."

John, Volunteer Mentor | @johnbishop | Nov 26, 2023

Ed @njed, I take 1200 mg daily (600 mg morning and evening) of na-R-ALA which is a better form of R-ALA. I'm not sure the ALA is helpful since most sold as ALA contains 50% synthetic ALA (s-ALA) which is not as bioavailable as R-ALA or na-R-ALA. The labels should show the content of the s-ALA on the bottle when the product is labelled ALA. Then na-R-ALA is just one of the supplements I take for the neuropathy. The full list is in the Protocol 525 discussion here - https://connect.mayoclinic.org/discussion/have-you-tried-the-new-protocol-525-product-for-neuropathy-relief/. The supplement is no longer called the Protocol 525 since they've reduced the number of capsules to 4 in the morning, 2 at noon and 4 in the evening.

Here are a few reference articles on R-ALA on the topic.

--- (R)-Lipoic Acid: Unique ‘Mitochondrial Antioxidant’ Fights Premature Aging: https://nutritionreview.org/2019/07/r-lipoic-acid-unique-mitochondrial-antioxidant-fights-premature-aging/
--- Analysis of the Enhanced Stability of R(+)-Alpha Lipoic Acid by the Complex Formation with Cyclodextrins: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723188/

VIEW AND REPLY