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DiscussionNewly diagnosed with pancreatic mass — What questions to ask?
Pancreatic Cancer | Last Active: Dec 28, 2023 | Replies (21)Comment receiving replies
Replies to "Several links on questions to ask regarding treatment as well as one if surgery is an..."
FWIW, my oncologist stopped oxaliplatin after 8 cycles. He said that when he first began practice, physicians would continue with the Folfirinox regimen including oxaliplatin until the patient couldn't handle it anymore. By then, the neuropathy was painful, crippling and permanent. He said now he stops oxaliplatin after 8 cycles in an attempt to keep neuropathy at bay. Indeed, my neuropathy, which was still fairly mild, has resolved. Is this right for other patients? I have no idea; there seems to be such variation in treatment approaches. I have fortunately responded well to the overall Folfirinox-now-Folfiri treatment, so perhaps that's one reason my MD felt justified in dropping the oxali. But I mention it in case this info is of use to someone.
Thanks for the heads up. I already have severe neuropathy from an injury and I definitely need to avoid making it worse.
Great links, and I'm jealous of Dave's lab.
Abraxane to a large degree, and cisplatin to a lesser degree also cause chemo-induced peripheral neuropathy, and some studies have shown that compression therapy (alone or in combination with icing) can help. Compression alone is better than nothing for patients who can't tolerate the cold, and easier to use.
https://www.curetoday.com/view/cold-compression-may-prevent-chemo-induced-neuropathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810270/ (duplicate of your last link)
Icing (or at least cooling) may reduce the hair loss from Abraxane as well. I don't know how cold it has to be. It sounds more feasible than compression on the head, but it might be amusing observe some experiments in that area. 😉