Thanks for sharing this dosage adjustment experience. I find that the methenamine wiped me out. So I will try to modify this dosage. I’m taking D-Mannose twice daily along with cranberry twice daily. I also take Nettle and Oregano oil capsules nightly. Doing all I can to stay out of the doctor’s office. Using extra good hygiene, changing underwear twice daily. Drinking a ton of water. Sure hope all this helps.