Thank you, dene - I wish you and your dear wife strength and courage as you face this journey together. It's a tough, tough road. We all have the benefit of decades of progress in the sciences for this disease, genotyping being an important one. My understanding is that the more mutations you have, the better the chance of something "getting in" to target and kill those cancer cells. So... yeah... for your wife, she'll got a higher hill to climb with no mutations at all. But there's still hope for her! I'm hearing more and more stories about women who have survived this 10 years and longer. Hang onto that. When I had my first exploratory laparoscopy I enrolled in a study with Sloan Kettering that looked at over 500 mutations/alterations, and the results show that I have 4 mutations: TP53, RD1, PRDM14 and STK40. I have two alterations: FGFR1 and CCNE1, both of which are likely to respond to immunotherapy. I believe that treatment will be down the road a bit, once I'm past surgery and the post surgery chemo. Best to you both! Ruth