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Has anyone lowered their Abiraterone Dosage? To what effect?
Prostate Cancer | Last Active: Nov 17, 2023 | Replies (26)Comment receiving replies
dirtdancer: I was taking two abiraterone pills a day (2 x 500mg = 1,000mg, for almost two months), which I understood to be the standard dosage (in addition to 3-month Lupron injections). Were you taking 2,000mg per day (4 x 500mg)?
Also, did either doctor check your testosterone levels (which I understand is the purpose in taking abiraterone: to *assist* in lowering testosterone, intending to "starve" cancer cells and thereby lowering the PSA), and if so and the results were available to you, what were the testosterone levels on the 4 pills, then the 3 pills, and now the Erleada (and at what dosage?)?
Hopefully, the Erleada has been more uniformly and reliably efficacious, and *much less* of a problem for you!
Replies to "dirtdancer: I was taking two abiraterone pills a day (2 x 500mg = 1,000mg, for almost..."
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The answer from my P.A. regarding reduced Abiraterone dosage.....
I am attaching the below information regarding your question:
"Data from a small, phase 2 study suggest that abiraterone (Zytiga) 250 mg once daily administered with or within 30 minutes of a low-fat breakfast is noninferior to the standard dose (1,000 mg) administered on an empty stomach; prostate-specific antigen and progression-free survival results were similar between the 2 arms, although higher troughs were reported with the standard dose (Ref). Low-dose abiraterone may decrease patient financial burden and improve adherence for those in resource-poor settings; further study is necessary to determine long-term efficacy of this dosing approach. "
Given the small sample size and unknowns about long term efficacy, we do not routinely advise patients to proceed with this approach.