Short background:
I'm almost 74. Gleason 8, metastasis to various lymph nodes, seminal vesicals, bladder neck. I am on Abiraterone 1000mg (empty stomach) since Oct 2022 with Prednisolone 10mg (pred reduced to 5 mg since the last 5 months or so). I'm also on Goserelin 3 monthly (the last time I was given Leoprolide most probably because my treating hospital ran out off Goserelin). Jan-Feb this year I had 20 factions of Tomotherapy. My PSA now is 0.01. I've never got my testosterone tested.

I have several side effects (listed below) but I do not know whether Abiraterone is the cause or Goserelin (or for that matter Prednisolone):
* Total loss of libido
* Fatigue (almost always)
* Hot flashes (that I feel are more pronounced for a few weeks after injection of Gosarelin/Leuprplide)
* Tremendous increase in abdominal fat (I look obscene now)
* Signs of Gynecomastia (something that I have not found anyone discussing in this forum, which gives me the impression that I've been singled out for this reaction 🙂 )
* Perceptible loss of stamina (at times I feel tired just wiping myself after a bath)
* Recently started having pain in the hip bone, lower back, chest (pain gets relieved with self-massaging) (I'm meeting my doctor in 2 weeks)
* Dry Mouth (when it happens, I suck on a boiled sweet)
* Incomplete voiding (especially at night, this gets better as the day goes by)
* Fluid retention in the body

What the drugs have not been able to do is kill my smile and love for life. I'm enjoying life as much as before (barring a few activities that I just can't do). I ride by bike to the market, much to the consternation of my wifey; one has to see for themselves what driving conditions are in jam-packed Metros in India! I go for walks (now maybe only a kilometer or two where even 3 months ago I used to walk briskly for 5 kms). And lastly, I partake in the small pleasure of 60ml of Single Malt every evening (please, I'm not a good example to follow), devoid of which maybe, just maybe, I could have had lesser reactions to the drugs. But then, one has to, individually, settle for a balance between quality and quantity of life.