I did the Reclast infusion almost 4 weeks ago. Had some headaches, flu like symptoms, fatigue, but the weird thing was a swelling of the inside of my ankles with an almost throbbing ache. The literature I was given at the infusion leaned away from ibuprofen so I was taking Tylenol daily to take the edge off of the pain. I finally got sick of the aching and contacted my doc who said to go ahead and use ibuprofen -24 hrs later I am seeing good progress. Wish I had talked to her sooner. I had also had a knee repair in July prior to the infusion in Oct, and my repaired knee swelled up about 2weeks after the infusion. I guess u never know how the infusion will affect you. Fingers crossed that I don’t have anymore issues and can finally get back to my daily walks for exercise-I’ve gained about 10 lbs thru this ordeal.